Dubai-based Emirates airline placed an order for 150 of Boeing's new 777 mini-jumbos, in a $76bn (£47bn) deal.
Other orders from Etihad Airways, Qatar Airways and Lufthansa for some 109 of the new 777, previously codenamed 777X, brought its sales total to $95bn.
Emirates has also ordered 50 Airbus A380s, in a deal worth $23bn.
The airline is already the biggest customer of the A380 and the new deal will bring its total orders for the plane to 140.
And local rival Etihad Airways has also announced a firm order for 87 Airbus aircraft - some 50 A350 XWBs, 36 A320neo aircraft and one A330-200F as part of its fleet modernization strategy.
The deal - valued at $19bn - includes options for 30 more planes.
Boeing said its 777 mini-jumbo sales represented "the largest product launch in commercial jetliner history by dollar value".
"The response to the 777X has been astounding," Boeing chairman James McNerney added at the official launch the new plane in Dubai.
The 777 will come in two models, one seating 350 passengers, and another seating 406 people.
Boeing's new aircraft is designed to compete with the largest version of Airbus's A350 in the mini-jumbo market.
European rival Airbus has launched a campaign for a minimum standard seat width of 18 inches on long trips, as it seeks to draw the focus of airlines to what it says will be the 777's narrower seats.
Meanwhile, Airbus will be looking to sell more of its A380 super-jumbo aircraft, the world's biggest passenger aircraft, which is facing a potential cut in production unless some more orders are secured.
UK Prime Minister David Cameron has visited the airshow site, with the UK competing with France for a potential 60-plane fighter jet deal with the United Arab Emirates.
At Dubai Airshow, Boeing Scores Huge $130B Payday
Its 777X appears to be big winner, with at least 225 orders
By the Associated Press
Posted Nov 17, 2013 6:11 AM CST(AP) – Boeing Co.'s planned 777X long-haul airliner grabbed the bulk of orders today at the first day of the Dubai Airshow, with at least 225 planes on the books in an eye-popping display of the spending power and aggressive expansion efforts of Gulf carriers. In total, Boeing says that it netted at least 367 orders in deals believed to exceed $130 billion at the Middle East's premier aviation fair. Boeing CEO James McNerney Jr. called it part of the "largest commercial launch in aviation history" for a planned aircraft: the bigger and more fuel-efficient model of the company's popular 777 wide-body.
European rival Airbus opened the five-day airshow by announcing a $23 billion order for 50 A380s—its main competition for the 777X—by Dubai-based Emirates. This year's airshow appears on track to surpass the record $155 billion in deals in the 2007 event before the global economic downturn. Boeing received orders for 150 777X planes from Emirates, 50 from Qatar Airways and 25 from Abu Dhabi's Etihad Airways; it also inked deals with Etihad for 30 of its 787-10 Dreamliners and one cargo plane, and with budget carrier flydubai for 111 of its single-aisle 737 models. Boeing is still finalizing plans for the 777X—aiming to deliver the first aircraft by the end of the decade—but it has said it is expected to carry as many as 400 passengers and to be 20% more fuel efficient than the current 777.